Search results for "Disseminated cancer"

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Detection and quantification of mammaglobin in the blood of breast cancer patients: can it be useful as a potential clinical marker? Preliminary resu…

2006

BACKGROUND: Mammaglobin is expressed mainly in mammary tissue, overexpressed in breast cancer (BC) and rarely in other tissue. The aim of this study was to assess the sensitivity and specificity of transcript MGB1 detection and to evaluate the role of MGB1 as potential clinical marker for the detection of disseminated cancer cells in the blood of BC patients. PATIENTS AND METHODS: A consecutive series of 23 BC tissues, 36 peripheral blood BC samples and 35 healthy peripheral blood samples was prospectively recruited to investigate MGB1 expression by means of a quantitative Real Time RT-PCR assay. RESULTS: MGB1 overexpression in tissue samples of BC patients is significantly associated only …

OncologyAdultmedicine.medical_specialtyPathologySettore MED/06 - Oncologia MedicaMrna expressionClinical markerBreast NeoplasmsSensitivity and SpecificityMammaglobinBreast cancerInternal medicinemedicineBiomarkers TumorHumansUteroglobinProspective StudiesRNA MessengerProspective cohort studyAgedAged 80 and overbiologybusiness.industryReverse Transcriptase Polymerase Chain ReactionMammaglobin AMammary tissuemammaglobyn brest cancerHematologyMiddle Agedmedicine.diseaseNeoplastic Cells CirculatingPeripheral bloodNeoplasm ProteinsOncologybiology.proteinFemalebusinessDisseminated cancer

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